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TARGET 1 and TARGET 2 trials on IBS patients without constipation had resulted in global symptom relief for at least 2 weeks within a treatment-free month

Conversely, CO-GHD patients tend to be less insulin-resistant than AO-GHD patients (84), and their IGF-I levels are generally lower than their AO-GHD counterparts due to relatively lower intra-portal insulin levels

There have also been case reports of birth defects in children with paternal exposure to isoretinoin

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