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Additives and ingredients: Some patients find that certain nonnutritive sweeteners, sugar alcohols (sorbitol, maltitol), or other additives may trigger gastrointestinal distress

Esta funcin ha cobrado particular relevancia clnica con el desarrollo de agonistas de GLP-1 para el tratamiento de la obesidad

Individuals with severe heart failure (NYHA Class IV) were largely excluded from major clinical trials, meaning safety data in this population remain limited

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