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Their primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , promoting satiety and reducing food intake Acting on appetite centres in the brain to decrease hunger signals Microdosing refers to the practice of using substantially lower doses of a medication than those typically prescribed for its licensed indications

GLP-1RA therapy was associated with reductions in total cholesterol, low-density lipoprotein cholesterol and triglyceride levels compared with placebo or other hypoglycaemic agents

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