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If side effects become intolerable at any dose level, dropping back to the previous dose for two to four additional weeks before attempting escalation again often allows successful progression

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Evidence has shown that L-carnitine can promote mitochondrial biogenesis by upregulating peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1), a master regulator of mitochondrial biogenesis [14] and that L-carnitine promotes mitochondrial protein acetylation, a chemical modification that improves mitochondrial function and protects against stressors