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Rare cases of hepatic fibrosis have been reported, particularly in patients consuming alcohol, which enhances the drugs conversion to etretinate, a more hepatotoxic metabolite

Kehrer-Sawatzki H, Kordes U, Seiffert S et al (2018) Co-occurrence of schwannomatosis and rhabdoid tumor predisposition syndrome 1

Pairing rice with protein (fish, chicken, legumes) and non-starchy vegetables creates balanced meals that maximize satiety and minimize post-meal blood sugar fluctuations

Increase Fiber Gradually: Fiber adds bulk to the stool, making it easier to pass

Combining medication with other strategies improves long-term success