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At concentrations of 1 pM1 nM, DSIP stimulated calcium-dependent release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro suggesting any antinociceptive effects observed in animal models may be mediated through endogenous opioid peptide release rather than direct receptor binding [7]

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GLP-1 receptor-mediated effects are the most well-characterised and include: Nausea, vomiting, and diarrhoea typically dose-dependent and most prominent during dose escalation Reduced appetite and early satiety Pancreatitis has been reported with GLP-1 receptor agonist class medicines

While they are often available for research purposes, their use as performance-enhancing drugs in competitive sports is generally prohibited