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It Reduces Appetite, Possibly by Increasing Appetite-Suppressing Hormones It Limits Liver Glucose Production and Improves Insulin Sensitivity Metformin is the most common treatment for type 2 diabetes because it mainly acts by lowering the amount of glucose released by the liver, according to Minisha Sood, MD, a board-certified endocrinologist in New York City

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Metabolic changes due to weight loss can compound this effect

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