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When to seek medical advice : If you suspect pancreatitis (severe abdominal pain radiating to the back, nausea, vomiting), stop your GLP-1 medication immediately and seek urgent medical attention via NHS 111, 999, or A&E Severe or worsening gastrointestinal symptoms despite probiotic use New symptoms such as persistent abdominal pain, bloody stools, or unexplained weight loss Signs of infection including fever, particularly if immunocompromised Before starting probiotics , women should inform their healthcare provider, particularly if they have diabetes requiring careful monitoring, as any dietary changes can affect glycaemic control