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The drugs appetite suppression makes hitting a 1,500-plus calorie deficit by accident easy, so plan meals rather than eating to appetite

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Dietary modifications that may support metabolic health include: Including a source of protein at each meal, as protein can stimulate GLP-1 release Including dietary fibre , particularly soluble fibre from vegetables, legumes, oats, and wholegrains, which may promote GLP-1 secretion through fermentation by gut bacteria Eating regular, balanced meals that align with the NHS Eatwell Guide recommendations Limiting ultra-processed foods high in refined carbohydrates and unhealthy fats Considering fermented foods such as yoghurt, kefir, and sauerkraut, which may benefit overall gut health, though direct effects on GLP-1 require further research Lifestyle factors that support metabolic health include: Regular physical activity , with both aerobic exercise and resistance training showing benefits for glucose metabolism

Ethical approval Ethics approval and consent to participate All methods were performed in accordance with the relevant guidelines and regulations of the Institutional Animal Care and Use Committee of ShanghaiTech University (Approval No