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Despite effective control of inflammation through disease-modifying antirheumatic drugs (DMARDs) or biologic therapies, a large proportion of RA patients have persistent moderate to high pain in a state of inflammatory remission, which significantly impacts their quality of life (McWilliams et al., 2019)

It should also be noted that these trials predominantly included relatively healthy older participants, as individuals with potential comorbidities such as cardiovascular or renal diseases were often excluded [12, 34]