Keshavarz-Bahaghighat H, Sepand MR, Ghahremani MH, Aghsami M, Sanadgol N, Omidi A, Bodaghi-Namileh V, Sabzevari O (2018) Acetyl-L-Carnitine attenuates Arsenic-Induced oxidative stress and hippocampal mitochondrial dysfunction
TXNRDs also serve as electron donors for the regeneration of small antioxidants, possibly recycling ascorbic acid (vitamin C), -lipoic acid, -tocopherol (vitamin E), and coenzyme Q 10 from their oxidized forms (8)
Mechanisms of action Preclinical studies document: Anxiolytic effect without sedation in classical tests (elevated plus maze, open field, light-dark box) GABAergic system modulation : allosteric potentiation of GABA-A observed ex vivo Enkephalin increase (endogenous opioid peptide) and serotonergic modulation Immunomodulatory effects inherited from tuftsin: macrophage activation, T-helper modulation Behavioural models Anxiolysis is measured via time spent in open arms of the elevated plus maze (EPM), visit ratio of central zones of open field , and exit latency in light-dark box
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