Tirzepatide is an approved, extensively studied dual agonist with a proven safety record, commercial availability, and the most comprehensive Phase 3 dataset in the GLP-1 class
Tirzepatide has shown favorable effects on cardiovascular risk markers including blood pressure, lipids, and inflammatory markers, but cardiovascular outcomes trials are still ongoing
86 Fracture risk A large French cohort study involving 14 253 VSG patients reported an overall major osteoporotic fracture incidence of 1.70 per 1 000 person-years, with specific rates for distal forearm/wrist (0.82), proximal humerus (0.37), clinical vertebral (0.29), and hip fractures (0.22)
Legitimacy and quality are not binary
Eligible patients may discuss FDA-approved Zepbound, compounded tirzepatide programs, insurance verification, and self-pay treatment options based on clinical needs and provider recommendations