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Peripheral blood samples were obtained from each ALS patient and control at two visits separated by 6 months

Melanotan 1 and Melanotan 2 are synthetic analogs of the naturally occurring hormone alpha-melanocyte-stimulating hormone (-MSH)

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Dulaglutide is a once-weekly GLP-1RA consisting of the fusion of two identical sequences (the N-terminal portion of the native GLP-1) covalently bound by a peptide linker to the Fc component of a modified human immunoglobulin G4 heavy chain [21]