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The adverse reactions, reported regardless of investigator assessment of causality in 5% of patients treated with Januvia 100 mg daily as monotherapy, Januvia in combination with pioglitazone, or Januvia in combination with glimepiride, with or without metformin, and more commonly than in patients treated with placebo, are shown in Table 1

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Lancet Diabetes Endocrinol 10(6):393406

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10.1016/S0304-4165(01)00235-5 10 AsadaK

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This fragmented approach limits the sustainability of therapeutic effects, particularly in hypothyroid patients with profound metabolic and inflammatory dysregulation

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