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Some protocols use two-week escalation intervals with higher starting doses

Hypothyroidism, even in its subclinical form, is associated with: Higher fasting insulin Increased HOMA-IR (a measure of insulin resistance) Elevated fasting glucose and hemoglobin A1C in some cases While GLP-1s can improve glycemic control, their effectiveness may be reduced in the presence of uncontrolled thyroid disease

Among antihyperglycemic agents, SGLT2is are widely recognised for their early cardiorenal protection in CKD, including protection from and management of heart failure (HF), independent of glucose levels and ejection fraction