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Although only a small percentage of NPs penetrate the epithelial barrier of alveolar and gastrointestinal tracts, and transfer into secondary tissues and organs (9), this low rate of internalization may have considerable consequences due to long-term exposure of humans to plastic particles and the potential of accumulation

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J Hazard Mater 416:126124

Transition metals such as copper, iron and zinc are essential for normal physiological functions

Hypoxia promotes the production of several gene products implicated in tumor development, invasion, and metastasis formation of gastric cancer