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doi:10.1038/s41586-026-10330-z 24.Bezin J, Bnard-Laribire A, Hucteau E, et al

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These are based largely on expert opinion and multi-society consensus, which may lead to variations in clinical practice both regionally and globally

49 A recent systematic review and meta-analysis involving obese individuals without diabetes demonstrated that tirzepatide, semaglutide, liraglutide, and exenatide significantly increased the risk of GI adverse events compared with placebo

But fatigue sits in the background, confusing new users because it doesnt feel like normal tiredness