discontinue sulfonylurea when starting glp-1 receptor agonist and the kidney: from physiology to pharmacology and outcomes in diabetes GLP-1 Receptor Agonists at the

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Exercise during the protocol Resistance training is more important than cardio during a caloric deficit supported by appetite-suppressing peptides

Medical conditions affecting absorption warrant particular attention : Pernicious anaemia : an autoimmune condition destroying gastric parietal cells, requiring lifelong B12 injections Gastrointestinal surgery : particularly gastric bypass, gastrectomy, or terminal ileum resection Inflammatory bowel disease : Crohn's disease affecting the terminal ileum impairs absorption Coeliac disease : untreated disease damages the small intestine, reducing B12 uptake Medication use : long-term metformin therapy (MHRA safety alert) or nitrous oxide exposure Symptoms suggesting possible B12 deficiency include : persistent fatigue, weakness, paraesthesia (pins and needles) in hands or feet, glossitis (sore, red tongue), mood changes, memory problems, or unexplained anaemia

no FDA or EMA trials

WO: HELSINGIN YLIOPISTO OP - FI 20205738 A