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Figure 1 Tumor development and progression depend on the interactions between cancer cells and multiple cell types surrounding the tumor, constituting the tumor microenvironment (TME) ( This review summarizes the data obtained from various studies to explore the benefits of QUE in combination with various chemotherapeutic agents, which manifest in two aspects: enhanced chemotherapy sensitivity and reduced toxic side effects of chemotherapy

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Emerging therapies targeting ferroptosisincluding inhaled nanoparticles delivering GPX4 mRNA or siRNA against ER/ACSL4show promise in preclinical models by selectively inhibiting lipid peroxidation without systemic immunosuppression ( 5 Immune cells and ferroptosis in asthma Immune cells are central contributors to the pathogenesis of asthma, but their roles extend beyond simple pro- versus anti-ferroptotic categorization