In Studies 2 (NCT#03548935), 3 (NCT#03552757), and 4 (NCT#03611582), WEGOVY or matching placebo was escalated to 2.4 mg subcutaneous weekly during a 16-week period followed by 52 weeks on maintenance dose
However, the HPA axis will then respond to these heightened cortisol levels by decreasing the production of cortisol over time
Furthermore, reconstitution of wildtype (100) or LDL receptor deficient mice( Ldlr -/- ) (101) with Apoe -/- bone marrow accelerates atherosclerotic lesion development without affecting plasma cholesterol levels, demonstrating an atheroprotective role for macrophage apoE
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