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Potential Complications of Combining the Two If an individual with gastroparesis takes a medication that further slows the gut, several complications can arise

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Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Sowers M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt KD, Fries JF (2000) Osteoarthritis: new insights

The additional GIP receptor activation in retatrutide likely accounts for this difference by creating synergistic metabolic effects beyond what dual agonism achieves