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Research has also explored its interaction with pathways associated with: Fibrosis-related signaling Oxidative-stress regulation Chronic inflammationrelated pathways Cellular-maintenance and adaptive-response mechanisms Because of its broad interaction with regenerative signaling pathways, GHK-Cu is frequently investigated in skin-integrity, healthy-aging, tissue-maintenance, and recovery-focused research models

doi: 10.1111/j.1365-2265.2008.03348.x 85 BaskolGAtmacaHTanriverdiFBaskolMKocerDBayramF

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Researchers frequently employ *in vitro* models, such as primary cell cultures or established cell lines, where oxidative insults are induced using agents like hydrogen peroxide, menadione, or paraquat