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reported that in MITOL knockdown-mediated ferroptosis in cardiomyocytes, knockdown of ChaC1 reversed cell injury and increased GSH [53]

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These findings confirm that while the GLP-1 RAs do not materially increase rare adverse events such as pancreatitis and severe hypoglycaemia, gastrointestinal side effects represent a predictable and clinically relevant class effect that often limits tolerability