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Clinical trials have demonstrated substantial weight loss outcomes, with patients losing an average of approximately 15% of their body weight over 68 weeks with semaglutide 2.4 mg weekly in the STEP 1 trial

NPR pointed out that the drugmakers themselves have advertised heavily, with some commercials including the number of pounds patients lost even when that particular medication was meant for type 2 diabetics

Circulation 2016;134:752-72.ArticlePubMed 29

In addition, as MASLD was associated with higher mortality from a wide range of causes, a holistic approach is likely required to effectively reduce the risk of excess mortality in patients with MASLD