Glutathione is thought to brighten skin in two linked ways: by inhibiting tyrosinase (the key enzyme in pigment production) and by shifting melanin synthesis from darker eumelanin toward lighter pheomelanin
Anaesthesia 63:8991 Temple AR, Benson GD, Zinsenheim JR, Schweinle JE (2006) Multicenter, randomized, double-blind, active-controlled, parallel-group trial of the long-term (612 months) safety of acetaminophen in adult patients with osteoarthritis
Also, since it affects melanin, pair it with broad-spectrum protection from our sunscreen category to prevent rebound darkening from sun exposure
However, using PCCA Glutathione (L) Reduced EP (Pharma Grade) (PCCA # 30-5100 ) topically at a concentration of 20% in a permeation-enhancing base, such as Lipoderm (PCCA # 30-3338 ) or PermE8 Anhydrous Gel (PCCA # 30-5038 ), works faster than oral administration
Ethosomes: a novel drug carrier