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Journal of Parkinsons Disease , 7(2), 289299

10.1007/BF02326961

doi: 10.4414/smw.2014.13944 77 LamKM

Current advances in local protein synthesis and synaptic plasticity

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Localized erythema (injection site) Transient hyperpigmentation (topical, in some users) Rare contact dermatitis Known interactions Vitamin C (theoretical copper-ascorbate redox cycling) Retinoids (may potentiate irritation when stacked topically) Contraindications Wilson's disease (copper-accumulation disorder) Active malignancy at the local site (theoretical, due to angiogenic activity) REGULATORY STATUS FDA Topical GHK-Cu formulations are marketed as cosmetic ingredients under FDA cosmetic regulation (cosmetics generally do not require FDA premarket approval)