In many countries, AOM supply is not granted by the public healthcare service, making affordability an extremely relevant issue for treatment access and persistence
For the same reasons, female participants were advised to promptly inform the investigators in case of a suspected pregnancy, to be withdrawn from the study and to assess treatment continuation on a case-by-case basis
Very frustrating
[PMID: 15059236] [5] Duthoit C, Estienne V, Giraud A, Durand-Gorde JM, Rasmussen AK, Feldt-Rasmussen U, Carayon P, Ruf J
p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk