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Dehydration frequently accompanies early semaglutide use because the medication reduces appetite and thirst signaling, yet fluid needs remain high during active weight loss

This makes it more targeted for fat loss without the broader effects on growth and IGF-1 levels

Our guidance offers patients a one-stop shop for our up-to-date advice on how to use these powerful medicines safely

Written by Jordan Caulfield & medically reviewed by Dr, Lilla Csonka: : June 06, 2026 GLP-1 has quickly become one of the most discussed topics in weight management and metabolic health

A significant proportion of depressed adolescents and adults systematically use substances, or substance use disorder (SUD), and approximately 13 million adults in 2023 had serious thoughts of suicide, made a suicide plan, or attempted suicide in the past year [1]