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It is important to note that when fat cells grow larger, they release nicotinamide N-methyltransferase (NNMT), which slows down metabolism and further leads to weight gain

doi: 10.1016/j.jacc.2008.10.033

Additional heterogeneity arises from diverse interventions (different formulations, routes, dosages, durations) and inconsistent comparators, compounded by non-uniform outcome definitions and diagnostic criteria for liver injury

Conversely, phentermine may antagonize sedative medications, for example, it can reduce the efficacy of beta-blockers or other blood pressure drugs

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