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lag-2(q411) is homozygous lethal and is a likely molecular null allele as it is caused by an early stop codon [24]

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used heparinase inhibitors and a heparinase-deficient mouse model to demonstrate the pathogenic role of heparanase activation in sepsis-induced respiratory distress (53), and a similar phenomenon was identified in a model of ischemic acute kidney injury (66, 67)