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The hypothesis that deficient serotonergic neurotransmission contributes to the pathogenesis of MDD originated from clinical observations that amine-depleting drugs induced depressive states, whereas monoamine oxidase inhibitors, which prevent the breakdown of serotonin (5-HT), alleviated depressive symptoms [4, 5]

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Typically, our patients receive the recommended 4-6 treatments and after about one year they will receiving one treatment every six months to maintain the results

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