The largest Phase 2b trial (502 participants, 24 weeks) did not show statistically significant weight loss versus placebo
This study also compared the effect of glutathione monoethyl ester on the externalization of PS, on days 35 and 42, and found that there was a significant difference between the two groups, which agrees with another study
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Measurable weight loss typically becomes apparent on the scale within 2 to 4 weeks, though initial losses may include both fat and water weight
With the caveat that this case series includes only four cases, it appears that narrower optic nerve heads may pose a greater risk for semaglutide-associated NAION, potentially independent of systemic risk factors