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At subacute timepoints, these PCs and PEs (particularly those containing polyunsaturated fatty acids) as well as SMs and LPC 20:2 are downregulated, while diaglycerols and free fatty acids/polyunsaturated fatty acids are increased in serum of rats with TBI [87]

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Moreover, several large-scale clinical trials 6,7,8,9,10 such as LEADER, SUSTAIN-6, and REWIND have demonstrated that GLP-1RAs can reduce the incidence of MACEs in patients with T2D and established cardiovascular disease or high cardiovascular risk