Eli Lilly is targeting an FDA submission in late 2026
Secondary endpoints at the 12mg dose included: fasting insulin reduction of 41%, triglyceride reduction of ~40%, waist circumference reduction of 18.5 cm, and meaningful improvements in liver fat fraction on MRI in a subset of participants
Likewise, the accelerated aging of both the brain and blood vessels emerged as significant independent indicators of progression into Alzheimers disease, demonstrating predictive power comparable to plasma pTau-181 levels
However, not everyone can tolerate the side effects of the shots
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