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J Clin Endocrinol Metab 82 : 727734 Jorgensen JO et al

Once the plunger is fully depressed, withdraw the needle at the same angle it was inserted

By year 2, headache rates were identical in both groups, indicating that the medication-related excess seen in shorter trials doesnt persist long term

This result contrasts with some previous studies on DSIPs neuroprotective effects that have reported reduction in infarct size in other models [1]

The timing aligns with the period when acetaminophen became ubiquitous in pregnancy and early childhoodaffecting both prenatal brain development and postnatal exposures during critical developmental windows