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These cation-selective ligand-gated ion channels are activated by the excitatory neurotransmitter glutamate and mediate fast excitatory synaptic transmission in mammalian brains 1,2

There are studies on the change in expression of the D14 gene in response to various stresses, including drought 151,152,153 , heavy metals 154 , and light 155

The experimental protocol is illustrated in Figure 1A

420,421 Another limitation of CPPs is their limited clinical efficacy, often requiring high concentrations and doses to achieve a therapeutic effect, which can cause significant toxicity and side effects, hindering the development of clinical applications

It is believed that ACs, especially LAC, might become potential biomarkers for the diagnosis of depression and effective drugs for their treatment of depression in the future given their important clinical value