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doi: 10.1016/j.redox.2015.07.012, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 30.Sinha R, Sinha I, Calcagnotto A, Trushin N, Haley JS, Schell TD, et al

The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary