Eli Lilly reported dysesthesia was "generally mild" and "rarely led to discontinuation." TRIUMPH-1 the larger general obesity trial with 2,339 patients at 80 weeks confirmed dysesthesia also occurs outside the osteoarthritis population, though at a lower rate than in TRIUMPH-4
These medications are less commonly used today because sulfonylureas can cause hypoglycemia, and thiazolidinediones may lead to weight gain
Abraham SC, Krasinskas AM, Correa AM, Hofstetter WL , Ajani JA, Swisher SG, Wu TT
Semaglutide, liraglutide, dulaglutide, and related agents improve glycemic control, promote weight loss, and may reduce cardiovascular risk in selected patients
Common adverse reactions include nausea, vomiting, diarrhea, and constipation, primarily due to delayed gastric emptying and hormonal effects on the digestive system