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In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improved GSH deficiency, OxS, mitochondrial fatty-acid oxidation (MFO), and insulin resistance (IR)

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doi: 10.3389/fmed.2025.1608975

The right strategy depends on the cause, metabolic health, nutrition, activity, and treatment being used