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GRAS simply means the FDA agrees that the substance, at intended use levels as a food additive or supplement, is safe based on common use history or expert opinion and does not pose acute toxicity concerns

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Hypoglycemia (Low Blood Sugar) Because IGF-1 mimics insulin, it can cause increased glucose uptake into cells which, without adequate carb intake, may lead to symptoms of hypoglycemia (shakiness, fatigue, dizziness)

Since melanin brings dark pigment to your skin, regulating its production will promote skin brightening