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no hepatic safety signal has been observed across the orforglipron clinical program, distinguishing it from the discontinued Pfizer oral GLP-1 candidates lotiglipron and danuglipron, both of which were terminated due to liver toxicity concerns

For researchers who have been purchasing semaglutide through these channels, this regulatory pressure is likely to reshape availability and pricing in the near term

Obesity science & practice , 10(2)

In fact, significant weight loss from Mounjaro may slightly reduce peripheral oestrogen production, since fat tissue naturally produces oestrogen through aromatisation

Rizzo initiated this study after discovering anecdotal evidence