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cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

Consulting a healthcare provider is advised

Due to their effectiveness, GLP-1-based medicines have become fundamental in obesity pharmacotherapy, with current investigations into next-generation multi-agonists (e.g., retatrutide) aimed at improving results [39]

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