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Several viral infections, and the progression of virus-induced diseases, especially those associated with COVID-19, are characterized by an alteration in the intracellular redox balance (Polonikov, 2020)

Gastric peptidases cleave the tripeptide bond on contact, breaking glutathione into its constituent amino acids before it reaches the small intestine

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In addition, drug-metabolizing pathways, especially cytochrome P450, varied significantly across iHLO development, with highly enriched PPAR signaling, a pathway critical for hepatocyte differentiation and lipid metabolism