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Although precise hepatic anti-inflammatory mechanisms remain incompletely defined, proposed pathways include reduction of lipotoxicity-induced cellular stress, modulation of hepatic macrophage activity, and direct effects on inflammatory signaling cascades [26]

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Patients should tell their doctor if each dose increase brings stronger nausea, fatigue, reflux, constipation, or inability to eat

Overview of Available GLP-1 RAs in the UK and Europe A number of GLP-1 RAs have been approved in the UK and Europe for the treatment of T2D (Table 1)