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Some evidence suggests that antioxidants may both lower immune cell NLRP3 activity and decrease the propagation of peripheral inflammation into brain parenchymal tissue [76, 141,142,143]
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But there are several obstacles to the development of this senolytic approach such as the long-term effect of CAR-T cells therapy with possible aspecific toxicity in different organs 56 , the cost and the difficulty during process development 57 or the selection of non-exhausted T cells to generate efficient therapy 58,59
Canadian researchers at McMaster University have published extensively on this topic, demonstrating that body composition quality predicts long-term weight maintenance success better than total pounds lost
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