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This is likely due to a reduction of peptide interactions (mainly A5 Cagri ) with ECL3 that is a consequence of the engagement of the lipidated N-terminus with the top segment of TM5/ECL2, facilitating flexibility of ECL3

The GLUT4 receptor does not get sent off to the membrane to open and let the glucose in the cell

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Funding This work was supported by the National Natural Science Foundation of China (32002184 to BW), the ZhiYuan project of Inner Mongolia Medical University (ZY0120025 to LS), and the Key Technology Research, Development and Transformation Projects of Inner Mongolia (2021GG0402 to YD and 2022YFSH0102 to YM)