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When the drug is removed, the compensatory biology that defends a higher body-weight set point reasserts itself

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It is dissolved with 4ml of distilled water and is directly injected either by intravenous (recommended) or intramuscular route

Strengths of the present meta-analysis are the inclusion of all CVOTs published by 10 December 2021, the very large number of participants, the high quality of the trials which minimizes the risk of bias, and the absence of significant heterogeneity in most analyses, which ranged from absent to low or moderate

NFL levels were also lowered suggesting motor neuron protection, and exploratory clinical end points looked favourable in the high-dose arm