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Because NNMT intersects NAD salvage, pairing with NMN/NR is a common experimental strategy to test additive or synergistic effects on cellular NAD and metabolic endpoints

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For more detail on -syn and mitochondrial dysfunction in PD, please see the excellent review by Rocha et al

Likewise, given during reperfusion after clamping the common carotid arteries, BPC 157 reduced stroke (i.e., both early and delayed hippocampal neural damage, achieving full functional recovery in the Morris water maze test, inclined beam-walking test, and lateral push test) (Vukojevic et al., 2020) or reduced L-NAME-induced retinal ischemia in rats (Zlatar et al., 2021)

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