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Glutamate-cysteine ligase catalytic and modulator subunits as well as GSH synthetase are the three NRF2 targets involved in the GSH synthesis (242)

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With regard to the primary endpoint of cardiovascular death plus hospitalisation for heart failure, there was a 17% reduction (HR = 0.83, 95% CI 0.71 to 0.98) in the group with established atherosclerotic cardiovascular disease

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