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A key question raised by these findings is whether in women, the phase of the menstrual cycle similarly impacts responsiveness to GLP1R agonists, but unfortunately, reliable information regarding menstrual cycle phase could not be deciphered from our EMR data set

Lactate further inhibits the antitumor activity of T cells by upregulating immune checkpoint molecules like PD-L1, providing an important metabolic basis for tumor immune escape through this multiple-action mechanism (86)